TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-65 KDa and the accession number is Q62312-2.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 580 | 5日内发货 | ||
50 μg | ¥ 1,410 | 5日内发货 | ||
500 μg | ¥ 9,960 | 5日内发货 | ||
1 mg | ¥ 14,200 | 5日内发货 |
生物活性 | Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells. The ED50 for this effect is 69.07 ng/ml in the presence of 1ng/ml of recombinant human TGF-beta 1. (Regularly tested) |
产品描述 | TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 55-65 KDa and the accession number is Q62312-2. |
种属 | Mouse |
表达系统 | HEK293 Cells |
标签 | C-hFc |
蛋白编号 | Q62312-2 |
别名 | TGF-β receptor type II, Tgfbr2, TGF-β receptor type-2, TGF-β type II receptor, Transforming growth factor-β receptor type II, Transforming growth factor-beta receptor type II, TβR-II, TGF-beta type II receptor, TGF-beta receptor type-2, TbetaR-II, TGF-beta receptor type II, TGFR-2 |
氨基酸序列 | Ile24-Asp159 |
蛋白构建 | Ile24-Asp159 |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 55-65 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinity cell surface receptors: TGF-β receptor type I (TGF-β-RI), TGF-β receptor type II (TGF-β-RII), and TGF-ββ receptor type III (TGF-β-RIII). TGF-β RII is consists of a C-terminal protein kinase domain and an N-terminal ectodomain and belongs to transforming growth factor-beta (TGF-β) receptor subfamily. TGF-β RII has a protein kinase domain which can form a heterodimeric complex with another receptor protein and bind TGF-beta. This receptor/ligand complex phosphorylates protein will enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. |
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TGFBR2 Protein, Mouse, Recombinant (aa 24-159, hFc) TGF-β receptor type II TGFR 2 TGF-b type II receptor Tgfbr2 TGF-β receptor type-2 TGF-β type II receptor Transforming growth factor-β receptor type II Transforming growth factor-beta receptor type II Transforming growth factor-b receptor type II TβR-II TGF-b receptor type-2 TGF-beta type II receptor TGFR2 TGF-beta receptor type-2 TGF-b receptor type II TbetaR-II TGF-beta receptor type II TGFR-2 recombinant recombinant-proteins proteins protein