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Peroxiredoxin 2 Protein, Human, Recombinant (His)

产品编号 TMPY-02200

别名: PRP, HEL-S-2a, TSA, NKEF-B, TDPX1, PTX1, TPX1, peroxiredoxin 2, PRX2, PRXII, NKEFB

Peroxiredoxin 2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P32119.

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Peroxiredoxin 2 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货

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参考文献

生物活性	Measured by its ability to reduce H2O2. The specific activity is >300 pmoles/min/μg.
产品描述	Peroxiredoxin 2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 24 kDa and the accession number is P32119.

种属	Human
表达系统	Baculovirus Insect Cells
标签	N-His
蛋白编号	P32119
别名	PRP, HEL-S-2a, TSA, NKEF-B, TDPX1, PTX1, TPX1, peroxiredoxin 2, PRX2, PRXII, NKEFB
蛋白构建	The Human PRDX2 (P32119) (Met 1-Asn 198) was expressed, with a polyhistidine tag at the N-terminus.
蛋白纯度	> 92 % as determined by SDS-PAGE
分子量	24 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 100 mM NaCl, pH 8.0, 10% gly. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Peroxiredoxin-2, also known as Natural killer cell-enhancing factor B, NKEF-B, Thiol-specific antioxidant protein, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, PRDX2 and NKEFB, is a cytoplasm protein that belongs to the ahpC / TSA family. Peroxiredoxin-2 / PRDX2 contains one thioredoxin domain. Peroxiredoxin-2 / PRDX2 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system. Peroxiredoxin-2 / PRDX2 is not able to receive electrons from glutaredoxin. It may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-2 / PRDX2 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The Peroxiredoxins / Prx are a family of peroxidases that can reduce H2O2 using an electron from thioredoxin (Trx) or other substances. The mammalian Peroxiredoxins / Prx family is divided into six groups (PRDX1，PRDX2, PRDX3, PRDX4, PRDX5, PRDX6) on the basis of homology of amino acid sequences. They are located in the cytosol and play a role in the cell signaling system. All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxins / Prx is overexpressed in breast cancer tissues to a great extent suggesting that Peroxiredoxins / Prx has a proliferative effect and may be related to cancer development or progression.

参考文献

1. Cha M.-K., et al., 1995, Biochem. Biophys. Res. Commun. 217:900-7. 2. Noh,D.Y. et al., 2001, Anticancer Res. 21 (3B): 2085-90. 3. Chevallet M., et al., 2003, J. Biol. Chem. 278:37146-53. 4. Schremmer,B. et al., 2007, Subcell Biochem. 44 :317-44. 5. Gauci S., et al., 2009, Anal. Chem. 81:4493-501.

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Keywords

Peroxiredoxin 2 Protein, Human, Recombinant (His) TDPX 1 PRP TDPX-1 HEL-S-2a TSA PRX 2 NKEF-B TDPX1 PTX1 PTX 1 TPX-1 PRX-2 TPX1 peroxiredoxin 2 PRX2 PTX-1 PRXII NKEFB TPX 1 recombinant recombinant-proteins proteins protein

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