LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His)

LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.4 kDa and the accession number is XP_005570011.1.

规格	价格/CNY		数量
50 μg	￥ 2,260	现货
100 μg	￥ 4,010	5日内发货
200 μg	￥ 7,090	5日内发货
500 μg	￥ 15,000	5日内发货

规格

价格/CNY

货期

数量

50 μg

￥ 2,260

现货

100 μg

￥ 4,010

5日内发货

200 μg

￥ 7,090

5日内发货

500 μg

￥ 15,000

5日内发货

生物活性	1. Immobilized LAG3 Protein, Cynomolgus, Recombinant (74 Pro, His Tag) at 2 μg/mL (100 μL/well) can bind FGL1 Protein, Cynomolgus, Recombinant (hFc Tag), the EC50 is 140-760 ng/mL. 2. Immobilized Recombinant Cynomolgus LAG3/CD223(74 Pro,His Tag) at 2μg/mL (100μL/well) can bind Anti-LAG3(BMS)-IgG4 Antibody , the EC50 is 60-180 ng/mL.
产品描述	LAG-3 Protein, Cynomolgus, Recombinant (74 Pro, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.4 kDa and the accession number is XP_005570011.1.

种属	Cynomolgus
表达系统	HEK293 Cells
标签	C-His
蛋白编号	XP_005570011.1
别名	lymphocyte-activation gene 3
蛋白构建	The cynomolgus LAG3 (XP_005570011.1) (Met1-Leu450, 74 Pro) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	47.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy