Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the relocalization of EPHA2 away from sites of cell-cell contact during transformation. Ephrin-A1 plays an important role in angiogenesis and tumor neovascularization.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 740 | 5日内发货 | ||
50 μg | ¥ 1,970 | 5日内发货 | ||
500 μg | ¥ 12,100 | 5日内发货 | ||
1 mg | ¥ 17,400 | 5日内发货 |
产品描述 | Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the relocalization of EPHA2 away from sites of cell-cell contact during transformation. Ephrin-A1 plays an important role in angiogenesis and tumor neovascularization. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | C-hFc |
蛋白编号 | AAH32698.1 |
别名 | TNFAIP4, LERK1, Tumor Necrosis Factor α-Induced Protein 4, Immediate Early Response Protein B61, Ephrin-A1, EPH-Related Receptor Tyrosine Kinase Ligand 1, TNF Alpha-Induced Protein 4, EFNA1, EPLG1, TNF α-Induced Protein 4, Tumor Necrosis Factor Alpha-Induced Protein 4, LERK-1 |
氨基酸序列 | Asp19-Ser182 |
蛋白构建 | Asp19-Ser182 |
蛋白纯度 | Greater than 85% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 55-60 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the relocalization of EPHA2 away from sites of cell-cell contact during transformation. Ephrin-A1 plays an important role in angiogenesis and tumor neovascularization. |
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EFNA1 Protein, Human, Recombinant (hFc) TNFAIP4 LERK1 LERK 1 EPLG 1 TNFAIP-4 Tumor Necrosis Factor a-Induced Protein 4 Tumor Necrosis Factor α-Induced Protein 4 Immediate Early Response Protein B61 TNFAIP 4 Ephrin-A1 EPH-Related Receptor Tyrosine Kinase Ligand 1 TNF Alpha-Induced Protein 4 EFNA1 EPLG1 EPLG-1 EFNA 1 TNF α-Induced Protein 4 TNF a-Induced Protein 4 Tumor Necrosis Factor Alpha-Induced Protein 4 EFNA-1 LERK-1 recombinant recombinant-proteins proteins protein