CD161 Protein, Human, Recombinant (N-hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 55-70 KDa and the accession number is Q12918.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 550 | 5日内发货 | ||
50 μg | ¥ 1,670 | 5日内发货 | ||
500 μg | ¥ 13,800 | 5日内发货 | ||
1 mg | ¥ 20,700 | 5日内发货 |
产品描述 | CD161 Protein, Human, Recombinant (N-hFc) is expressed in HEK293 mammalian cells with N-Fc tag. The predicted molecular weight is 55-70 KDa and the accession number is Q12918. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | N-hFc |
蛋白编号 | Q12918 |
别名 | Killer cell lectin-like receptor subfamily B member 1, HNKR-P1a, NKRP1A, KLRB1, CLEC5B, CD161, Natural killer cell surface protein P1A, C-type lectin domain family 5 member B, NKR-P1A |
氨基酸序列 | Lys68-Ser225 |
蛋白构建 | Lys68-Ser225 |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC. |
分子量 | 55-70 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Killer cell lectin-like receptor subfamily B, member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain. KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
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CD161 Protein, Human, Recombinant (N-hFc) Killer cell lectin-like receptor subfamily B member 1 CD 161 HNKR-P1a NKRP1A KLRB-1 KLRB1 CLEC5B CD161 CD-161 KLRB 1 Natural killer cell surface protein P1A C-type lectin domain family 5 member B NKR-P1A recombinant recombinant-proteins proteins protein