BMP-4 Protein, Mouse, Recombinant (rFc)

BMP-4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P21275.

规格	价格/CNY		货期	数量
10 μg	￥ 1,250	5日内发货
100 μg	￥ 4,920	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 1,250

5日内发货

100 μg

￥ 4,920

5日内发货

生物活性	Testing in progress
产品描述	BMP-4 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 40.6 kDa and the accession number is P21275.

种属	Mouse
表达系统	HEK293 Cells
标签	N-rFc
蛋白编号	P21275
别名	bone morphogenetic protein 4, Bmp-4, Bmp2b-1, Bmp2b, Bmp2b1
蛋白构建	The Mouse BMP4 (NP_031580.2) (Ser293-Arg408) was expressed with the Fc region of rabbit IgG at the N-terminus..
蛋白纯度	> 92 % as determined by SDS-PAGE.
分子量	40.6 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.

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BMP-4 Protein, Mouse, Recombinant (rFc)

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