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BCMA/TNFRSF17 Protein, Rat, Recombinant (hFc)

BCMA/TNFRSF17 Protein, Rat, Recombinant (hFc)

产品编号 TMPY-02913
别名: tumor necrosis factor receptor superfamily member 17

BCMA/TNFRSF17 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 34 kDa and the accession number is D3ZKQ8.

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BCMA/TNFRSF17 Protein, Rat, Recombinant (hFc)
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 5日内发货
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产品目录号及名称: BCMA/TNFRSF17 Protein, Rat, Recombinant (hFc) (TMPY-02913)
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生物活性 Testing in progress
产品描述 BCMA/TNFRSF17 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 34 kDa and the accession number is D3ZKQ8.
种属 Rat
表达系统 HEK293 Cells
标签 N-hFc
蛋白编号 D3ZKQ8
别名 tumor necrosis factor receptor superfamily member 17
蛋白构建 The Rat TNFRSF17 (D3ZKQ8) (Met1-Thr49) was expressed, fused with the Fc region of Human IgG1 at the N-terminus.
蛋白纯度 > 99 % as determined by SDS-PAGE
分子量 34 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

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Keywords

BCMA/TNFRSF17 Protein, Rat, Recombinant (hFc) tumor necrosis factor receptor superfamily member 17 recombinant recombinant-proteins proteins protein

 

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