ANGPT1/Angiopoietin-1 Protein, Cynomolgus, Recombinant (His)

ANGPT1/Angiopoietin-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.9 kDa and the accession number is XP_005563980.1.

规格	价格/CNY		货期	数量
100 μg	￥ 3,930	5日内发货
1 mg	￥ 22,200	5日内发货

规格

价格/CNY

货期

数量

100 μg

￥ 3,930

5日内发货

1 mg

￥ 22,200

5日内发货

生物活性	Testing in progress
产品描述	ANGPT1/Angiopoietin-1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.9 kDa and the accession number is XP_005563980.1.

种属	Cynomolgus
表达系统	HEK293 Cells
标签	N-His
蛋白编号	XP_005563980.1
别名	angiopoietin 1
蛋白构建	cynomolgus ANGPT1 (XP_005563980.1) (Arg277-Phe498)
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	27.9 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. A role for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure. By linking ANGPT1 with PCG, these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development.

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ANGPT1/Angiopoietin-1 Protein, Cynomolgus, Recombinant (His)

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