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15-PGDH Protein, Human, Recombinant (His)

15-PGDH Protein, Human, Recombinant (His)

产品编号 TMPY-01264
别名: PGDH1, hydroxyprostaglandin dehydrogenase 15-(NAD), PHOAR1, SDR36C1, 15-PGDH, PGDH

15-PGDH Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 29.7 kDa and the accession number is P15428-1.

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15-PGDH Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
50 μg ¥ 3,820 5日内发货
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产品目录号及名称: 15-PGDH Protein, Human, Recombinant (His) (TMPY-01264)
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产品性质
参考文献
生物活性 Measured by the production of NADH during the oxidation of PGF2α. The specific activity is >1,500 pmoles/min/μg.
产品描述 15-PGDH Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 29.7 kDa and the accession number is P15428-1.
种属 Human
表达系统 E. coli
标签 C-His
蛋白编号 P15428-1
别名 PGDH1, hydroxyprostaglandin dehydrogenase 15-(NAD), PHOAR1, SDR36C1, 15-PGDH, PGDH
蛋白构建 The Human HPGD (NP_000851.2) (Met 1-Gln 266) was expressed, with a polyhistidine tag at the C-terminus.
蛋白纯度 > 92 % as determined by SDS-PAGE
分子量 29.7 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Supplied as sterile 50 mM Tris, 100 mM NaCl, 0.5 mM DTT, 10% glycerol, pH 7.5.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing.

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Keywords

15-PGDH Protein, Human, Recombinant (His) PGDH1 PGDH-1 hydroxyprostaglandin dehydrogenase 15-(NAD) PHOAR-1 PHOAR 1 PGDH 1 PHOAR1 SDR36C1 15-PGDH PGDH recombinant recombinant-proteins proteins protein

 

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